![]() We evaluated how the liver macro- and microstructures affect the electric field distribution. The mean electric field threshold that best fitted the zone of coagulation necrosis was 1225 V/cm, while the mean threshold that best fitted the zone of partially damaged liver parenchyma attributed to IRE was 805 V/cm. We compared the computed results with histopathological changes identified on microscopic images after treatment. We numerically reconstructed four ECT experiments in healthy porcine liver and computed the electric field distribution using our treatment planning framework. In this study, we investigate electroporation in the liver using a numerical mesoscale tissue model. The success of ECT and IRE depends on sufficient electric field established in whole target tissue therefore, tissue heterogeneity may affect the treatment outcome. The liver is a highly heterogeneous organ, permeated with a network of macro- and microvasculature, biliary tracts and connective tissue. Electrochemotherapy (ECT) and irreversible electroporation (IRE) are being investigated for treatment of hepatic tumours.
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